The use of Local Vitamin D3 Gel in Immediate Dental Implants: A Randomized Controlled Study

Aim: This study was performed to evaluate the osteogenic efficacy of vitamin D3 on immediate dental implant by clinical and radiographic assessments. Subjects and methods: This was a prospective randomized, clinical study including 30 patients with decayed hopeless tooth indicated for extraction and seeking implant placement. Patients were selected from those attending at the outpatient clinic of Oral Medicine and Periodontology Department, Faculty of Dental Medicine, Al-Azhar University “Assiut branch” seeking extraction and dental implant placement. The patients were divided into two groups: Group (1): 15 patients received immediate dental implant placement alone used as control group, and Group (2): 15 patients received extraction combined with dental implant placement plus local application of vitamin D3 gel on the socket as test group. Results: There was no statistically significant difference between two groups in visual analogue scale (VAS) at day 1, and 14 but there was a statistically significant decrease in group 2 at day 3, and 7 compared to group 1. According to modified plaque index, there was no statistically significant difference between two groups at 3 months and at 6 months. Moreover, the modified plaque index means were statistically different across different time periods in group 1 only, but not statistically different in group 2. Regarding probing depth, there was no statistically significant difference between the two groups at baseline, 3 months and 6 months. However, the probing depth means were statistically significant different across different time periods when compared in each study group (decreases by time). Conclusion: The current study showed that topical application of Vitamin D3 in immediate dental implant placement mildly improves osseointegration and may induce anti-inflammatory effect in peri-implant status