A comprehensive, multi-center, immunogenomic analysis of melanoma brain metastases
The mutational landscape and gene expression of MBM from the Duke cohort resembled those previously reported in the MDACC cohort. Upregulation of autophagy pathways was observed in patient-matched MBM versus LN and skin metastases due to upregulation of two genes, GFAP and HBB. In MBM, higher M2:M1 ratio may contribute to a therapeutically relevant immune-suppressive tumor microenvironment (TME).
Authors
- Xiaodi Qin (ORCID: https://orcid.org/0000-0001-7066-8151)
- Amanda E.D. Van Swearingen (ORCID: https://orcid.org/0000-0002-4287-9741)
- Carey K. Anders (ORCID: https://orcid.org/0000-0001-9165-4074)
- Dadong Zhang (ORCID: https://orcid.org/0000-0001-6419-8886)
- Alexander B. Sibley (ORCID: https://orcid.org/0000-0003-4552-1865)
- Marissa R. Lee (ORCID: https://orcid.org/0000-0001-7188-9933)
- Kouros Owzar (ORCID: https://orcid.org/0000-0002-3340-1287)
- Swaminathan Kumar (ORCID: https://orcid.org/0000-0002-9358-787X)
- Lucy Boyce Kennedy (ORCID: https://orcid.org/0000-0001-6644-8922)
- Eric Lipp (ORCID: https://orcid.org/0000-0002-4372-5533)
- Michael A. Davies (ORCID: https://orcid.org/0000-0002-0977-0912)
- Jeff Sheng
- Layne W. Rogers (ORCID: https://orcid.org/0000-0002-4881-5589)
- Pixu Shi (ORCID: https://orcid.org/0000-0002-2455-2622)
- Aron Y. Joon (ORCID: https://orcid.org/0000-0003-2615-2179)
- April K.S. Salama (ORCID: https://orcid.org/0000-0002-8105-5374)
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Duke University (US)
- Duke Medical Center (US)
- Duke University Hospital (US)
Publication Details
- Journal
- Acta Neuropathologica Communications
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s40478-025-02035-7
- Citations
- 1
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- American Cancer Society
- Melanoma Research Alliance
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- AIM at Melanoma
- National Cancer Institute