Bone regeneration using moldable calcium phosphate with and without recombinant human BMP-2 in a rabbit critical-sized metaphyseal core defect model
The MCaP carrier demonstrated strong osteoconductive potential and was sufficient to support bone healing compared to autograft in a metaphyseal defect model. The addition of rhBMP-2 promoted earlier bone formation. However, long-term studies in more challenging bone healing environments are warranted to further assess the clinical utility of rhBMP-2 in bone regeneration.
Authors
- Mi Young Ryu
- Hyung‐Youl Park (ORCID: https://orcid.org/0000-0002-0084-8867)
- Sang-Il Kim
- Young-Hoon Kim (ORCID: https://orcid.org/0000-0002-6151-6911)
- Hyun Jung Park (ORCID: https://orcid.org/0000-0002-8324-2624)
- Hyun Ryu (ORCID: https://orcid.org/0009-0000-5507-5833)
Institutions
- St. Mary's Hospital (US)
- KoreaBio (KR)
- St. Mary's Hospital (US)
- The Catholic University of Korea Seoul St. Mary's Hospital (KR)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13018-025-05966-y
- Citations
- 1
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 0.67
Funders
- National Research Foundation
- University of New South Wales
- National Research Foundation of Korea