Dextrose prolotherapy at varying concentrations ameliorates tendon injury via IGF-2R: an integrated study of Mendelian randomization and an animal model
Hypertonic dextrose downregulates IGF-2R expression, upregulates vascular endothelial growth factor and transforming growth factor-β1 expression, modulates collagen synthesis, increases type I collagen content, and accelerates tendon healing. Among the tested concentrations, 25% hypertonic glucose yielded the best therapeutic outcomes.
Authors
- Kai Hu (ORCID: https://orcid.org/0000-0002-3325-5101)
- Lina Zhou (ORCID: https://orcid.org/0000-0002-4439-9274)
- Xixia Liu (ORCID: https://orcid.org/0000-0003-4972-4694)
- Yulin Chen (ORCID: https://orcid.org/0000-0001-9710-4436)
- Hui Liang (ORCID: https://orcid.org/0000-0003-1460-8335)
Institutions
- Guangxi University of Chinese Medicine (CN)
- The People's Hospital of Guangxi Zhuang Autonomous Region (CN)
Publication Details
- Journal
- Journal of Orthopaedic Surgery and Research
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s13018-025-05977-9
- Citations
- 1
- Primary Topic
- Tendon Structure and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- National Natural Science Foundation of China