The mechanisms of Brucea javanica in the treatment of oral squamous cell carcinoma: a network pharmacology, molecular docking, and experimental study
Brucea javanica exhibits multi-target and multi-pathway characteristics in the treatment of oral squamous cell carcinoma, potentially exerting its anti-cancer effects by inhibiting the EGFR/PI3K/AKT signaling pathway.
Authors
- Yujie Ma (ORCID: https://orcid.org/0000-0001-7758-2625)
- Juan Zhan (ORCID: https://orcid.org/0000-0002-2535-0811)
- Yisen Shao
- Yanqing Lai (ORCID: https://orcid.org/0000-0001-6192-8759)
- Jie Zha (ORCID: https://orcid.org/0009-0009-7428-9410)
- Wei Wang (ORCID: https://orcid.org/0000-0001-7656-0782)
- Mingkang Li (ORCID: https://orcid.org/0000-0003-1329-0230)
- Lin Jiang (ORCID: https://orcid.org/0000-0003-1528-9727)
- Haiyan Wei (ORCID: https://orcid.org/0000-0003-3393-0792)
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Nanchang University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-06-02
- DOI
- https://doi.org/10.1186/s40001-025-02686-1
- Primary Topic
- Phytochemical compounds biological activities
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province
- Education Department of Jiangxi Province
- Jiangxi University of Traditional Chinese Medicine