Oxidative stress in branched-chain organic acidemias using thiol-disulfide homeostasis
The parameters of the TDH are altered in patients with OA, especially in those with MMA and PA, indicating a significant level of oxidative stress. The neurodevelopmental outcome in OA may be exacerbated by this oxidative imbalance. The utilization of TDH as a biomarker may be a potential provider of oxidative status in OA patients and facilitate informing therapeutic strategies.
Authors
- Hakim Çelık (ORCID: https://orcid.org/0000-0002-7565-3394)
- Emine Pektaş (ORCID: https://orcid.org/0000-0002-9742-2087)
- Mehmet Keskın (ORCID: https://orcid.org/0000-0002-5544-8991)
- Burcu Kumru Akın
Institutions
- Gaziantep Children's Hospital (TR)
- Gaziantep University (TR)
- Adnan Menderes University (TR)
- Harran University (TR)
Publication Details
- Journal
- Journal of Pediatric Endocrinology and Metabolism
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1515/jpem-2025-0184
- Primary Topic
- Metabolism and Genetic Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00