Predictive value of doppler ultrasound blood flow indicators and placental growth factors in patients with severe preeclampsia

This study aimed to improve the diagnostic efficacy of severe preeclampsia (SP) and enhance fetal outcomes by investigating the predictive value (PV) of 3D energy Doppler ultrasound flow parameters and maternal peripheral blood placental growth factor (PLGF). Clinical data were obtained from 105 SP patients and 100 normal controls (NC). Ultrasound was used to measure blood flow parameters such as the systolic/diastolic velocity ratio (S/D), resistance index (RI), and pulsatility index (PI) in the uterine, umbilical, and middle cerebral arteries (MCA). Additionally, PLGF levels were assessed. Receiver operating characteristic (ROC) curves were used to evaluate the PV of these ultrasound parameters and PLGF levels. The results revealed significantly higher maternal blood pressure and lower fetal parameters, such as amniotic fluid index and fetal weight, in the SP group compared to the NC group (P<0.05). The combination of ultrasound blood flow parameters and PLGF levels showed the best predictive performance for SP, with sensitivity of 91.43%, specificity of 90.00%, and an AUC of 0.896. These findings suggest that combining ultrasound and PLGF measurements offers a reliable method for predicting severe preeclampsia.