Optimization of Extraction of Volatile Compounds from Cinnamomum camphora (L.) J. S. Presl Leaves Using Microwave-Assisted Hydro-Distillation Method

Cinnamomum camphora (L.) J. S. Presl is a major source of volatile compounds, particularly camphor which has been shown to possess antiseptic, analgesic, and anti-inflammatory properties.  This study aimed to identify the optimal conditions for extracting volatile compounds from C. camphora (L.) J. S. Presl leaves. The volatile compounds from  C. camphora (L.) J. S. Presl leaves were extracted using the Microwave-Assisted Hydro-Distillation (MAHD). The chemical composition of the volatile compounds was analyzed using gas chromatography-mass spectrometry (GC-MS). To determine the optimal extraction conditions of the volatile compounds, the Response Surface Methodology (RSM) was applied by manipulating three crucial parameters - microwave power (W), solvent-to-material ratio (w/w), and extraction duration (min). The results demonstrated that under the optimal conditions of 430 W microwave power, a solvent-to-material ratio of 9.3:1, and an extraction time of 77 minutes, pulverized C. camphora (L.) J. S. Presl leaves yielded volatile compounds with a maximum yield of 4.23 ± 0.04%. these findings have provided insights into the chemical composition of volatile compounds from C. camphora (L.) J. S. Presl leaves, and the optimum conditions for their extraction.