Formulation and Evaluation of Semi-Synthetic Anti -Microbial Cream

The objective of this study was to investigate the antimicrobial properties of the Umbelliferae family of plants. Previous research has shown that extracts from fennel, coriander, and cumin exhibit significant antimicrobial effects. To further explore these properties, we formulated and evaluated a cream containing extracts of alovera, coriander, and cumin oil, focusing on its antimicrobial activity. The cream was created using various excipients, including borax, beeswax, white soft paraffin, and additional ingredients such as methylparaben, propylparaben, and distilled water. Each formulation was assessed for pH, viscosity, spreadability, washability, homogeneity, physical characteristics, stability, irritancy, and antimicrobial efficacy. The prepared cream underwent evaluations of its physical, rheological, and antimicrobial properties, along with phytochemical screening for terpenoids and microbial assays. Stability studies were also conducted. The findings revealed promising antimicrobial activity, indicating the potential of the herbal cream as a natural alternative for combating microbial infections. Antimicrobial susceptibility testing confirmed the cream's effectiveness against a range of microbial pathogens. Throughout the research, formulation F2 was identified as the most effective, exhibiting no phase separation and demonstrating significant antimicrobial activity, leading to its selection as the preferred formulation.