The Correlation Between Calgranulin C (S100A12) Levels And Different Dermatological Diseases

Introduction: Calgranulin C plays a crucial role in the body's inflammatory response. It serves as a biomarker for inflammation and autoimmune conditions, including dermatological diseases. Aim of the study: To assess the relation between the levels of Calgranulin C (S100A12) and the development of different dermatological diseases.Subjects and Methods: We searched Cochrane, Web of Science, PubMed, and SCOPUS for relevant articles. We utilized a strategy for our search by combining these keywords: (‘’ Calgranulin C ’’ OR ‘’ S100A12 ’’) AND (‘’ psoriasis ‘’ OR ‘’ atopic dermatitis ‘’ OR ‘’ Acne ‘’ OR ‘’ scleroderma ‘’ OR ‘’ Systemic sclerosis ‘’ OR ‘’ dermatological diseases ‘’). Quality evaluation of the involved studies was assessed regarding to Cochrane’s risk of bias tool (ROB).Results: we found that the levels Calgranulin C affected by different skin diseases as individuals suffering from scleroderma, atopic dermatitis (AD), and psoriasis showed substantially higher levels of Calgranulin C than healthy participants. Conclusions: Calgranulin C is a significant player in the inflammatory pathways involved in various skin diseases. Its role as a pro-inflammatory mediator makes it a potential biomarker for disease activity and a target for therapeutic intervention..Keywords: Calgranulin C, scleroderma, systemic sclerosis, alopecia areata, psoriasis, atopic dermatitis