Organ-Specific Immune Response Controls Leptomeningeal Metastases

Major Finding: The leptomeningeal antitumor immune response is dependent on natural killer (NK) cell cytotoxic activity.Concept: Leptomeningeal IFNγ stimulates cytokine production by dendritic cells to promote NK cell activation.Impact: Targeting IFNγ signaling may augment the immune response against leptomeningeal metastases.

Publication Details

Journal
Cancer Discovery
Published
2025-01-01
DOI
https://doi.org/10.1158/2159-8290.cd-rw2025-049
Primary Topic
Brain Metastases and Treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Organ-Specific Immune Response Controls Leptomeningeal Metastases

Cancer Discovery
Brain Metastases and Treatment
article

Organ-Specific Immune Response Controls Leptomeningeal Metastases

article en

Abstract

Major Finding: The leptomeningeal antitumor immune response is dependent on natural killer (NK) cell cytotoxic activity.Concept: Leptomeningeal IFNγ stimulates cytokine production by dendritic cells to promote NK cell activation.Impact: Targeting IFNγ signaling may augment the immune response against leptomeningeal metastases.

Cancer Discovery
Zero hunger
Openalex Percentile: Top 79%
Brain Metastases and Treatment
DOISourceOpenAlex
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