Prevention of chronic disease using vitamins—a case study of the vitamin D and cardiovascular disease hypothesis using evidence from randomised controlled and prospective cohort studies
This example illustrates the complexity of conducting nutrient trials and raises questions about RCTs of single nutrients for complex chronic diseases. The core challenge common to all nutrient trials is the absence of a zero-intake placebo group and variable background exposures. Alternative approaches and interpretation paradigms are required.
Authors
- Lorraine Brennan (ORCID: https://orcid.org/0000-0002-7711-7499)
- Máiréad Kiely (ORCID: https://orcid.org/0000-0003-0973-808X)
- Travis Dunlop
- Jayne V. Woodside (ORCID: https://orcid.org/0000-0002-5691-4659)
- Diego Moretti (ORCID: https://orcid.org/0000-0002-7366-2182)
- Guillermo Tate
Institutions
- University College Dublin (IE)
- Queen's University Belfast (GB)
- University College Cork (IE)
- Food for Health Ireland (IE)
- Swiss Distance University of Applied Sciences (CH)
Publication Details
- Journal
- European Journal of Nutrition
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1007/s00394-025-03706-w
- Citations
- 4
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.89
Funders
- Irish Research eLibrary
- University College Cork