Rhein Alleviates Cisplatin-Induced Acute Kidney Injury via Downregulation of NOX4-COX2/PGFS Signaling Pathway
Rhein protects against CDDP-induced AKI by inhibiting oxidative stress and inflammation through targeting the NOX4-NFκB-COX2/PGFS pathway, without compromising CDDP's antitumor activity. These findings highlight Rhein as a promising adjunctive therapy for CDDP-associated nephrotoxicity.
Authors
- Baien Liang (ORCID: https://orcid.org/0009-0001-4722-471X)
- Long Xu (ORCID: https://orcid.org/0000-0003-3487-3929)
- Xi Yuan (ORCID: https://orcid.org/0000-0002-1110-9349)
- Minghui Wang (ORCID: https://orcid.org/0000-0002-5788-894X)
- Weidong Wang (ORCID: https://orcid.org/0000-0003-2523-3145)
- Wenhao Chen (ORCID: https://orcid.org/0000-0002-0626-3739)
- Chunling Li (ORCID: https://orcid.org/0000-0002-9381-2686)
- Luosha Long
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/dddt.s515409
- Citations
- 2
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 2.94