Branched‐Chain Amino Acids and Di‐Alanine Supplementation Attenuates Muscle Atrophy in a Murine Model of Cancer Cachexia
Collectively, these results highlight that innovative formulations containing Di-Ala, capable of increasing BCAA bioavailability, may be efficacious in counteracting muscle atrophy, especially during mild-to-moderate cancer cachexia.
Authors
- Noemi Martella (ORCID: https://orcid.org/0000-0003-0455-1494)
- Giuseppina Caretti (ORCID: https://orcid.org/0000-0002-2322-6008)
- Michela Varone
- Gianluca Bianchini (ORCID: https://orcid.org/0000-0002-5030-8068)
- Daniele Pensabene (ORCID: https://orcid.org/0009-0009-1624-170X)
- Mayra Colardo (ORCID: https://orcid.org/0000-0003-3353-8918)
- Marco Segatto (ORCID: https://orcid.org/0000-0003-0465-9470)
- Andrea Aramini (ORCID: https://orcid.org/0000-0001-8390-6614)
Institutions
- University of Molise (IT)
- University of Milan (IT)
- IBSA Farmaceutici (Italy) (IT)
- Dompé (Italy) (IT)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1111/apha.70067
- Citations
- 9
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 7.25
Funders
- Associazione Italiana per la Ricerca sul Cancro