Neural Tissue‐Like, not Supraphysiological, Electrical Conductivity Stimulates Neuronal Lineage Specification through Calcium Signaling and Epigenetic Modification (Adv. Sci. 35/2024)
Conductivity‐Dependent Neuronal Specification In article number 2400586, Hae‐Won Kim, Jung‐Hwan Lee, and co‐workers show that neural‐tissue‐like, low conductivity (0.02–0.1 S m–1) promotes neuronal differentiation via balanced calcium signaling and epigenetic changes, while supraphysiological, high conductivity (3.2 S m–1) causes apoptosis. This work reveals optimal conductivity's crucial role in neural interface design for tissue engineering and regenerative medicine. [Image: see text]
Authors
- Ji‐Young Yoon
- Yunkyu Choi
- Bo‐Eun Yoon
- Yunseong Ji (ORCID: https://orcid.org/0000-0002-2048-153X)
- Jonathan C. Knowles (ORCID: https://orcid.org/0000-0003-3917-3446)
- Y.W. Kim
- Jeong‐Hui Park
- Rajendra K. Singh (ORCID: https://orcid.org/0000-0003-3127-3346)
- Yuxuan Meng
- Hae‐Hyoung Lee
- Hwalim Lee (ORCID: https://orcid.org/0000-0002-9685-5710)
- Amal George Kurian (ORCID: https://orcid.org/0000-0002-6510-7429)
- Jung‐Hwan Lee (ORCID: https://orcid.org/0000-0001-8678-5459)
- Yu‐Jin Kim (ORCID: https://orcid.org/0000-0003-2562-615X)
- Yumeng Li (ORCID: https://orcid.org/0000-0002-9986-5201)
- Hae‐Won Kim
Publication Details
- Journal
- Advanced Science
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/advs.202470215
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00