Oxygen-Generating Biomimetic Nano-Herb System for Synergistic Therapy & Pain Relief in Triple-Negative Breast Cancer via HIF-1α/VEGF Pathway
The novel (Q+M/MnOx)@Clip system represents a promising advancement in nanomedicine, improving the bioavailability of quercetin and offering a more effective approach to cancer treatment by downregulation of HIF-1α and VEGF-A. This study demonstrates the potential for combining anti-tumor immunity with pain relief for triple-negative breast cancer therapy.
Authors
- D. S. Cao
- Youjie Li (ORCID: https://orcid.org/0000-0001-9296-0903)
- Peipei Sun (ORCID: https://orcid.org/0000-0002-1716-2343)
- Dong-Yang Wu
- Yongliang Chi (ORCID: https://orcid.org/0000-0002-7389-3108)
- Shuyang Xie (ORCID: https://orcid.org/0000-0002-8090-2180)
- Nana Wang
- Qin Wang (ORCID: https://orcid.org/0000-0001-8821-8677)
- Xia Zhang (ORCID: https://orcid.org/0009-0001-5748-4371)
- Ranran Wang (ORCID: https://orcid.org/0000-0001-7530-5608)
- Yanmei Li (ORCID: https://orcid.org/0000-0002-3531-5067)
- Ning Xie (ORCID: https://orcid.org/0000-0002-4628-2299)
- Hongfang Sun
- Yang Guo (ORCID: https://orcid.org/0009-0004-9822-5853)
- Pingyu Wang (ORCID: https://orcid.org/0000-0003-0980-4294)
- Yan Liang (ORCID: https://orcid.org/0000-0001-5594-2415)
Institutions
- Shandong University of Traditional Chinese Medicine (CN)
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Yantai University (CN)
- Yantaishan Hospital (CN)
- Affiliated Hospital of Shandong University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/ijn.s523754
- Citations
- 2
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 1.35