miR-155 targets SOCS1 to modulate the phenotype transition of M1 macrophage in distraction osteogenesis promoted by PTH administration
PTH downregulates miR-155 in new bone and macrophages during mandibular DO, increasing SOCS1 expression, reducing M1 macrophages, and enhancing bone regeneration by lowering inflammation.
Authors
- Lei Tian (ORCID: https://orcid.org/0000-0002-1929-3953)
- Zhenglong Tang (ORCID: https://orcid.org/0000-0001-6309-0486)
- Duchenhui Li
- Yongdi Li
- Zhishan Yang
- Yiheng Liu
Institutions
- Guiyang Medical University (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1186/s40001-025-02683-4
- Citations
- 2
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China
- Guizhou Medical University