The LIDPAD Mouse Model Captures the Multisystem Interactions and Extrahepatic Complications in MASLD (Adv. Sci. 35/2024)
Metabolic Dysfunction‐Associated Steatotic Liver Disease The LIDPAD model, a single‐mouse metabolic dysfunction‐associated steatotic liver disease (MASLD) model using thermoneutral housing and refined diet, replicates key human MASLD features, such as metabolic syndrome, gut dysbiosis, multiorgan dysfunction, and neurobehavioral anomalies in a short period. Hepatic transcriptomic‐guided staging confirms its close human relevancy, making it an invaluable tools for advancing translational liver disease research. More details can be found in article number 2404326 by Nguan Soon Tan, Walter Wahli, and co‐workers. [Image: see text]
Authors
- Mei Kong (ORCID: https://orcid.org/0000-0003-1734-3280)
- Walter Wahli (ORCID: https://orcid.org/0000-0002-5966-9089)
- Wei Tan (ORCID: https://orcid.org/0000-0002-5076-0206)
- Marcus Ivan Gerard Vos
- Harish Poptani (ORCID: https://orcid.org/0000-0002-0593-3235)
- S. Sendhil Velan (ORCID: https://orcid.org/0000-0002-4096-0722)
- Rachel Tee
- Haiyu Hong (ORCID: https://orcid.org/0000-0002-5317-1271)
- Norliza Binte Esmail Sahib
- Yingzi Liu (ORCID: https://orcid.org/0000-0001-9260-3113)
- Jadegoud Yaligar (ORCID: https://orcid.org/0000-0002-6050-5241)
- Aik Seng Ng (ORCID: https://orcid.org/0000-0003-1925-4759)
- Zoë Bichler (ORCID: https://orcid.org/0000-0003-1942-480X)
- Barbara Mickelson
- Christopher B. Ball (ORCID: https://orcid.org/0000-0002-5983-1605)
- Damien Chua (ORCID: https://orcid.org/0000-0003-0007-1688)
- Xue Li Guan (ORCID: https://orcid.org/0000-0002-5189-8178)
- Mark Dhinesh Muthiah (ORCID: https://orcid.org/0000-0002-9724-4743)
- Nguan Soon Tan (ORCID: https://orcid.org/0000-0003-0136-7341)
- Jing Qu (ORCID: https://orcid.org/0000-0002-3988-5067)
- Ser Sue Ng (ORCID: https://orcid.org/0000-0001-9873-9433)
- Nandini C. L. Rao
- Zun Siong Low
- Chaonong Cai
- Yun Sheng Yip
- Manesh Chittezhath
- Nicole Ashley Tan
- Hong Sheng Cheng (ORCID: https://orcid.org/0000-0001-9745-7872)
- Li Liang (ORCID: https://orcid.org/0000-0001-9584-6778)
- Yusuf Ali (ORCID: https://orcid.org/0000-0003-0753-3590)
- Sanjay Kumar Verma (ORCID: https://orcid.org/0000-0002-1111-1836)
- Debbie Xiu En Lim (ORCID: https://orcid.org/0000-0002-2772-0580)
- Yan Zhuang (ORCID: https://orcid.org/0000-0001-6286-1621)
- Aileen Wee
- Dao Liang Lim
- Jiapeng Chen
- Vanessa Shiyun Tay
Publication Details
- Journal
- Advanced Science
- Published
- 2024-09-01
- DOI
- https://doi.org/10.1002/advs.202470214
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00