Inflammatory chemokines in adolescents’ suicide state with depressive disorders

Suicide has become one of the leading causes of death in adolescents and is a direct consequence in patients with depressive disorders. Recently, neuroinflammation has been shown to play a role in the development of depression. This study examined serum chemokine levels in adolescents with depressive disorders at different suicide stages to identify chemokines that discriminate between suicidal behaviors. This study enrolled 111 adolescent patients with depressive disorders who were further subdivided into three groups based on the presence of suicidal behavior or ideation: suicide attempt group (n = 45), suicidal ideation group (n = 44), and non-suicidal depression group (n = 22), along with 23 healthy controls. Eight inflammatory chemokines were detected using the mesoscale discovery method. Patients in the suicide attempters group had higher levels of IL8, MCP-1, Eotaxin, and Eotaxin-3 than those in the non-suicide depression group. Eotaxin-2 had the greatest effect on suicidal behaviors of all factors.