The Role of Gliclazide as a Preferred Modern Sulfonylurea

Sulfonylureas (SUs) are a cornerstone in the management of type 2 diabetes mellitus (T2DM), with gliclazide emerging as a preferred agent among modern SUs due to its favorable pharmacological profile.This review explores gliclazide's pharmacology, efficacy, safety, and unique advantages in comparison to other SUs, such as glimepiride, emphasizing its role in managing T2DM, especially in complex clinical scenarios.Gliclazide is highlighted for its lower risk of hypoglycemia, cardiovascular benefits, antioxidant properties, renal safety, and potential for weight neutrality.The review also discusses its therapeutic implications and clinical evidence supporting its use as a first-line therapy in certain patient populations, particularly in regions with high accessibility to SUs.