Multi-omics analysis of human plasma reveals reprogramming of tryptophan metabolism associated with inflammation in Mycoplasma pneumoniae pneumonia in children
The reprogramming of tryptophan metabolism in pediatric MPP patients is characterized by upregulated kynurenine pathway and downregulated indole pathway, with potential regulatory crosstalk with inflammation. Our findings provide evidence for the role of tryptophan metabolism in MPP, highlighting its potential as novel therapeutic targets.
Authors
- Yuyi Tang (ORCID: https://orcid.org/0000-0003-2478-5431)
- Xian Fu (ORCID: https://orcid.org/0000-0003-2605-4050)
- Na Zang (ORCID: https://orcid.org/0000-0001-6658-6700)
- Hou-Hua Yin
- Ren Luo (ORCID: https://orcid.org/0000-0001-9508-5497)
- Fangfang Yang (ORCID: https://orcid.org/0000-0002-3348-6268)
- Heping Fang (ORCID: https://orcid.org/0000-0002-2064-1169)
- Wen Zhong (ORCID: https://orcid.org/0000-0002-7568-3112)
- Enmei Liu (ORCID: https://orcid.org/0000-0001-8503-6974)
- Jun‐Yan Liu (ORCID: https://orcid.org/0000-0002-3018-0335)
- Xiangyü Li (ORCID: https://orcid.org/0000-0002-8301-9959)
- Run Wang (ORCID: https://orcid.org/0000-0001-5570-6391)
- Dapeng Chen (ORCID: https://orcid.org/0000-0001-8412-581X)
- Xue Chen (ORCID: https://orcid.org/0000-0002-8141-2431)
- Yu Deng (ORCID: https://orcid.org/0000-0003-3467-4540)
Institutions
- Guangzhou Experimental Station (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1016/j.jinf.2025.106525
- Citations
- 5
- Primary Topic
- Pneumonia and Respiratory Infections
- Type
- article
- Field-Weighted Citation Impact
- 6.77
Funders
- Chongqing Municipal Education Commission
- National Key Research and Development Program of China