A Case Report of a Massive Pleural Effusion as an Unusual Presentation for a Rare Condition

Primary mediastinal B-cell lymphoma (PMBCL) is a rare but aggressive mature B-cell lymphoma arising from thymic B cells.PMBCL represents approximately 2 to 4% of non-Hodgkin lymphoma, with a predominance among females in the third and fourth decades [2].In this study, we report a case of a previously healthy 16-year-old female who presented to our primary health care Center with a dry cough for 6 weeks associated with unintentional weight loss and night sweats.On examination, decreased breathing sounds were noted on the right side of the chest.A chest x ray showed right sided massive pleural effusion, so patients referred to the hospital as a case of pleural effusion for investigation.Our case is unique because of the presentation of PMBCL with massive pleural effusion as the initial clinical manifestation for the disease, which is an uncommon initial presentation.Furthermore, the diagnosis at the age of 16 is highly unusual, as PMBCL typically occurs in individuals aged 30 -39 and often presents with compressive symptoms like SVC obstruction syndrome.