Epigenetic age acceleration mediates the association between low-grade systemic inflammation and cardiovascular diseases: insight from the NHANES 1999–2002
Our results demonstrate that EAAs mediate the association between systemic inflammation and CVD risk, highlighting the potential of a multi-target approach to inflammation and epigenetic modifications for personalized management to reduce CVD risk.
Authors
- Yingnan Lv (ORCID: https://orcid.org/0000-0002-5129-5887)
- Yang Yong-mei
- Jiadong Chi (ORCID: https://orcid.org/0000-0003-0329-0747)
- Huijiao Zhou
- Huabei Wu
- Z. Y. Lee
- Haiying Zhang (ORCID: https://orcid.org/0000-0003-1911-7957)
- Jin Zhong (ORCID: https://orcid.org/0000-0001-8790-1327)
- Xiaolang Chen (ORCID: https://orcid.org/0000-0002-1700-9728)
- Lancheng Wei
Institutions
- Guangxi Medical University (CN)
- Center for Genomic Science (IT)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1186/s13148-025-01895-z
- Citations
- 3
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 10.48
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province