Temporally resolved single-cell RNA sequencing reveals protective and pathological responses during herpes simplex virus CNS infection
This study identifies a unique population of virus-activated microglia with antiviral and proinflammatory properties and reveals monocytes to be a key driver of interactions driving pathology in the virus-infected brain.
Authors
- Marina Romero‐Ramos (ORCID: https://orcid.org/0000-0003-0970-578X)
- Line S. Reinert (ORCID: https://orcid.org/0000-0002-8317-0886)
- Kasper Thorsen (ORCID: https://orcid.org/0000-0003-0195-4685)
- Yonglun Luo (ORCID: https://orcid.org/0000-0002-0007-7759)
- Ida Hyllen Klæstrup (ORCID: https://orcid.org/0000-0003-2605-3955)
- Xin Lai (ORCID: https://orcid.org/0000-0002-6008-1792)
- Morten M. Nielsen (ORCID: https://orcid.org/0000-0001-5432-2396)
- Sara R. N. Jensen
- Lin Lin (ORCID: https://orcid.org/0009-0009-0921-9336)
- Xiangning Ding
- Søren R. Paludan
Institutions
- Steno Diabetes Centers (DK)
- Aarhus University (DK)
- Aarhus University Hospital (DK)
Publication Details
- Journal
- Journal of Neuroinflammation
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1186/s12974-025-03471-x
- Citations
- 7
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 5.90
Funders
- Danmarks Grundforskningsfond
- Lundbeckfonden
- Novo Nordisk Fonden
- European Research Council
- Danish Agency for Science and Higher Education