NSC632839 suppresses esophageal squamous cell carcinoma cell proliferation in vitro by triggering spindle assembly checkpoint-mediated mitotic arrest and CREB-Noxa-dependent apoptosis
These findings provided a novel anti-cancer mechanism of NSC632839 and highlighted it as a potential anti-tumor agent for the treatment of esophageal cancer.
Authors
- Ruiyi Yang (ORCID: https://orcid.org/0000-0003-1841-4749)
- Ping Chen (ORCID: https://orcid.org/0000-0002-8504-5552)
- Yangcheng Ma
- Tao Hu
- Beibei Sha
- Wenjing Huang (ORCID: https://orcid.org/0000-0002-5791-0369)
- Yue Du (ORCID: https://orcid.org/0000-0002-9855-011X)
- Yixuan Guo (ORCID: https://orcid.org/0000-0002-0229-3674)
- Jianxiang Shi (ORCID: https://orcid.org/0000-0002-4346-3895)
- Yuan Zhang (ORCID: https://orcid.org/0000-0002-8963-9526)
- Pei Li (ORCID: https://orcid.org/0000-0001-7276-6337)
- Miaomiao Li (ORCID: https://orcid.org/0000-0003-2132-6168)
- Shan Zhao (ORCID: https://orcid.org/0009-0001-1682-5934)
- Jie Yan (ORCID: https://orcid.org/0000-0002-5439-6018)
- Yaxin Sun
- Guanglong Dong (ORCID: https://orcid.org/0000-0002-2670-0609)
Institutions
- Zhengzhou University (CN)
- Xinjiang Institute of Engineering (CN)
- Second Affiliated Hospital of Zhengzhou University (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1186/s12935-025-03831-w
- Primary Topic
- Microtubule and mitosis dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00