Tenascin-C drives cardiovascular dysfunction in a mouse model of diabetic cardiomyopathy
Our findings indicate that in diabetes, TNC contributes to cardiac contractile dysfunction, myocardial fibrosis, oxidative stress, inflammation, and metabolic disturbances in diabetic mouse heart. These results implicate the potential of TNC inhibition as a novel therapeutic approach for treating DCM.
Authors
- Petra Lujza Szabó (ORCID: https://orcid.org/0000-0001-5465-8391)
- Sílvia A. Sousa (ORCID: https://orcid.org/0000-0001-9291-9169)
- Barnabás Váradi
- Bence Ágg (ORCID: https://orcid.org/0000-0002-6492-0426)
- Attila Kiss (ORCID: https://orcid.org/0000-0003-4652-1998)
- Karin Zins (ORCID: https://orcid.org/0000-0002-0202-2364)
- Seth Hallström (ORCID: https://orcid.org/0000-0002-3160-7388)
- Heidi Budde
- György L. Nádasy (ORCID: https://orcid.org/0000-0003-2057-2391)
- Mária Szekeres (ORCID: https://orcid.org/0000-0002-6967-1158)
- Sarah Costantino (ORCID: https://orcid.org/0000-0002-3003-7213)
- Ibrahim Aykac (ORCID: https://orcid.org/0000-0002-1346-6227)
- Ana Isabel Antunes Goncalves (ORCID: https://orcid.org/0009-0009-3428-3321)
- Francesco Paneni (ORCID: https://orcid.org/0000-0001-6483-7844)
- Christopher Dostal (ORCID: https://orcid.org/0000-0003-4961-6458)
- Lars H. Lund (ORCID: https://orcid.org/0000-0003-1411-4482)
- Camilla Hage (ORCID: https://orcid.org/0000-0002-4142-2416)
- Martin Bilban (ORCID: https://orcid.org/0000-0001-7043-7142)
- Dietmar Abraham (ORCID: https://orcid.org/0000-0001-6337-0058)
- Zsuzsanna Arnold
- Péter Ferdinandy
- Nazha Hamdani
- Bruno K. Podesser (ORCID: https://orcid.org/0000-0002-4641-7202)
- Simge Baydar
Institutions
- Semmelweis University (HU)
- Karolinska University Hospital (SE)
- Medical University of Graz (AT)
- University of Zurich (CH)
- University Hospitals of the Ruhr-University of Bochum (DE)
- Maastricht University (NL)
- Ludwig Boltzmann Institute for Cardiovascular Research (AT)
- University Hospital of Zurich (CH)
- St. Josef-Hospital (DE)
- Ludwig Boltzmann Institute for Cancer Research (AT)
- Medical University of Vienna (AT)
- Ruhr University Bochum (DE)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1186/s12933-025-02780-y
- Citations
- 8
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 11.11
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Karolinska Institutet
- Stockholms Läns Landsting
- Vetenskapsrådet