To Study Pv-a CO2 Gap with the Ratio of Pv-a CO2 Gap to Arterial-central Venous O2 Content Difference in Septic Shock

INTRODUCTION: Tissue hypoperfusion is frequently associated in patients of septic shock with organ failure. This can lead to an increase in morbidity and mortality of patients. This study aims to compare pCO(2) gap, Venous-Arterial CO(2) content to Arterial-Venous O(2) content difference ratio and lactate level in predicting mortality in patients with septic shock.(1,2) OBJECTIVE: To explore effectiveness of p(v-a)CO(2) gap, p(v-a)CO(2)/c(a-v)O(2) and lactate level in predicting mortality in patients of septic shock: A prospective observational study. MATERIALS AND METHOD: It is a prospective comparative single center study being conducted on 36 patients with effect from September 2024. Upon admission patients are divided into two groups randomly of eighteen in each group with written consent taken from patient/their family members.(3–5) INCLUSION CRITERIA: All patients, aged 18 years and above who fulfilled the criteria of sepsis diagnosis according to the Surviving Sepsis Campaign 2021 in septic shock are included. Exclusion criteria: Pregnant and lactating mothers, post-cardiac arrest resuscitated patient prior to ICU admission are excluded. RESULTS: The trends that we see till now (which is with 10 patients) is that pCO(2) gap, Venous-Arterial CO(2) content to Arterial-Venous O(2) content difference ratio and lactate level in patients with septic shock corresponds to higher values. As this is an ongoing study, the statistical analysis will be more concrete and it will be included in the final presentation.(6) DISCUSSION: Values of pCO(2) gap, Venous-Arterial CO(2) content to Arterial-Venous O2 content difference ratio and lactate level helps in predicting mortality in patients presenting with septic shock.