Anti-Tyrosinase and Radical Scavenging Activities of Selected Cassipourea Plants and Isolated 7-Methoxygeranin A: Traditional Use as Skin Lighteners
While <i>C. flanaganii</i> demonstrated the strongest anti-tyrosinase activity, C. gummiflua showed the highest antioxidant potential. Emodin 6,8-dimethyl ether emerged as a promising candidate for skin-lightening applications, warranting further in vitro and in vivo validation. These findings support the traditional use of <i>Cassipourea</i> species and highlight their potential for developing natural skin health products. Further studies are needed to explore the pharmacokinetics, safety, and efficacy of these compounds in clinical settings.
Authors
- Ahmed A. Hussein (ORCID: https://orcid.org/0000-0002-3877-9959)
- Masande Yalo (ORCID: https://orcid.org/0000-0001-9860-1629)
- Jamiu Olaseni Aribisala (ORCID: https://orcid.org/0000-0002-1015-1457)
- Adedayo Ayodeji Lanrewaju (ORCID: https://orcid.org/0000-0001-6093-8090)
- Saheed Sabiu (ORCID: https://orcid.org/0000-0001-7209-9220)
- Michael Paulse (ORCID: https://orcid.org/0000-0002-7233-1226)
- Fanie Rautenbach (ORCID: https://orcid.org/0000-0003-4227-2648)
- Ncoza Cordelia Dlova (ORCID: https://orcid.org/0000-0002-2425-3905)
- Jeanine L. Marnewick (ORCID: https://orcid.org/0000-0002-1819-1699)
- Nomakhosi Mpofana (ORCID: https://orcid.org/0000-0002-3007-1147)
- Halimat Yusuf Lukman (ORCID: https://orcid.org/0000-0001-9873-4915)
Institutions
- University of Cape Town (ZA)
- Cape Peninsula University of Technology (ZA)
- Durban University of Technology (ZA)
- University of KwaZulu-Natal (ZA)
Publication Details
- Journal
- Journal of Experimental Pharmacology
- Published
- 2025-05-01
- DOI
- https://doi.org/10.2147/jep.s504759
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Higher Education and Training