mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage
These data suggest that mTOR inhibition disrupts mitochondrial integrity in cardiomyocytes by promoting the degradation of prohibitins and OPA-1, leading to mitochondrial fragmentation and metabolic dysfunction, particularly under conditions of metabolic stress.
Authors
- Mayarling Francisca Troncoso (ORCID: https://orcid.org/0000-0002-3492-8283)
- Sergio Lavandero (ORCID: https://orcid.org/0000-0003-4258-1483)
- Camila López‐Crisosto (ORCID: https://orcid.org/0000-0003-1055-099X)
- E. Dale Abel (ORCID: https://orcid.org/0000-0001-5290-0738)
- Rodrigo Troncoso (ORCID: https://orcid.org/0000-0003-0796-5908)
- Valentina Parra (ORCID: https://orcid.org/0000-0002-0080-6472)
- Mario Chiong (ORCID: https://orcid.org/0000-0002-5174-6545)
- Jovan Kuzmicic (ORCID: https://orcid.org/0009-0009-5815-193X)
- Andrea del Campo (ORCID: https://orcid.org/0000-0003-3830-7334)
- Hugo Verdejo (ORCID: https://orcid.org/0000-0003-0078-4792)
- Úrsula Zúñiga-Cuevas (ORCID: https://orcid.org/0000-0002-9409-4612)
- Beverly A. Rothermel (ORCID: https://orcid.org/0000-0001-9037-6703)
- Leslye Venegas-Zamora (ORCID: https://orcid.org/0000-0002-7726-8801)
- Damián Gatica (ORCID: https://orcid.org/0000-0001-5052-3131)
- C. Vásquez (ORCID: https://orcid.org/0000-0003-2606-6860)
Institutions
- Universidad Andrés Bello (CL)
- University of California, Los Angeles (US)
- Pontificia Universidad Católica de Chile (CL)
- San Sebastián University (CL)
- Advanced Center for Chronic Diseases (CL)
- University of O'Higgins (CL)
- University of Chile (CL)
- The University of Texas Southwestern Medical Center (US)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-05-31
- DOI
- https://doi.org/10.1186/s12964-025-02240-w
- Citations
- 3
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Agencia Nacional de Investigación y Desarrollo
- National Institutes of Health