A Case of Severe Anaphylaxis Following Iohexol Administration

Iohexol is a typical iodinated radiocontrast medium that is widely used in imaging examinations. The molecular structure of iohexol, which contains iodine, can trigger a complex immune response, leading to anaphylactic reactions that may manifest as cardiovascular instability, respiratory distress, or even cardiac arrest. Timely identification and intervention are crucial to prevent long-term consequences. Therefore, information on clinical features and management strategies for iohexol-related anaphylaxis is important. Recent reports suggested that the overall incidence of ADRs and serious ADRs with non-ionic iodinated contrast media was about 1 % and 0.01 %, respectively. Here we report a case of a 55-year-old female with a known history of systemic hypertension and hyperthyroidism who presented to the radiology department for a CT scan of the neck with iohexol for further evaluation of her goitre, who developed a sudden onset of drowsiness with multiple episodes of vomiting and breathlessness following iohexol administration.