NeoPred: dual-phase CT AI forecasts pathologic response to neoadjuvant chemo-immunotherapy in NSCLC
Combining dual-phase CT and clinical variables, NeoPred reliably and non-invasively predicts pathological response to neoadjuvant chemo-immunotherapy in NSCLC, outperforms unaided expert assessment, and significantly enhances radiologist performance. Further multinational trials are needed to confirm generalizability and support surgical decision-making.
Authors
- Wenhai Fu (ORCID: https://orcid.org/0000-0001-6356-4952)
- Xiaomin Ge
- Yuan Zhang (ORCID: https://orcid.org/0000-0002-5097-7237)
- Chao Yang (ORCID: https://orcid.org/0000-0003-4181-5356)
- Hengrui Liang (ORCID: https://orcid.org/0000-0002-1155-5963)
- Guangjian Zhang (ORCID: https://orcid.org/0000-0003-0888-5723)
- Chudong Wang
- Linchong Huang (ORCID: https://orcid.org/0000-0002-0122-6226)
- Jianqi Zheng (ORCID: https://orcid.org/0000-0002-7545-6323)
- Zhigang Li (ORCID: https://orcid.org/0000-0001-5086-5334)
- Junke Fu (ORCID: https://orcid.org/0000-0001-9286-1446)
- Zhenlin Chen (ORCID: https://orcid.org/0000-0003-2100-1363)
- Ying Huang (ORCID: https://orcid.org/0000-0003-4756-7939)
- Zeping Yan (ORCID: https://orcid.org/0000-0003-2845-9748)
- Guan Wang (ORCID: https://orcid.org/0000-0001-9974-4867)
- Jia Zhang (ORCID: https://orcid.org/0000-0002-8763-6620)
- Zhichao Liu (ORCID: https://orcid.org/0000-0003-3542-0905)
- Huan Deng (ORCID: https://orcid.org/0000-0002-6144-2289)
- Bohao Liu (ORCID: https://orcid.org/0000-0001-6921-3539)
- Hong Yu (ORCID: https://orcid.org/0000-0002-7242-908X)
- Yu Jiang (ORCID: https://orcid.org/0000-0003-4551-9335)
- Hongxu Liu (ORCID: https://orcid.org/0000-0003-1828-1085)
- Runchen Wang (ORCID: https://orcid.org/0000-0003-1969-7859)
- Houlu Xiao
- Yuechun Lin (ORCID: https://orcid.org/0009-0004-8855-8355)
- Pingwen Yu
- Jianxing He
- Fei Cui
- Rui Wang (ORCID: https://orcid.org/0009-0005-8109-7688)
Institutions
- Shanghai Chest Hospital (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Guangzhou Electronic Technology (China) (CN)
- Liaoning Cancer Hospital & Institute (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1136/jitc-2025-011773
- Citations
- 6
- Primary Topic
- Radiomics and Machine Learning in Medical Imaging
- Type
- article
- Field-Weighted Citation Impact
- 8.16