Circulating immunoregulatory B cell and autoreactive antibody profiles predict lack of toxicity to anti-PD-1 checkpoint inhibitor treatment in advanced melanoma
Distinct B cell and antibody reactivities in patients with advanced melanoma share features with extrafollicular B cell responses in autoimmune diseases, may be protective from irAE and help predict outcomes to anti-PD-1.
Authors
- Thomas J Tull (ORCID: https://orcid.org/0000-0002-8329-8601)
- Ioannis Prassas (ORCID: https://orcid.org/0000-0002-7907-4576)
- Sophie Papa (ORCID: https://orcid.org/0000-0002-9063-7675)
- Matthaios Kapiris
- Gary Middleton (ORCID: https://orcid.org/0000-0001-5695-3474)
- Ashley Di Meo (ORCID: https://orcid.org/0000-0002-6538-2738)
- Lucy H. Booth
- Yin Wu (ORCID: https://orcid.org/0000-0003-4080-3935)
- Jitesh Chauhan (ORCID: https://orcid.org/0000-0002-3968-9234)
- Dhruva Biswas (ORCID: https://orcid.org/0000-0001-9141-5188)
- Sophia N. Karagiannis (ORCID: https://orcid.org/0000-0002-4100-7810)
- Esperanza Perucha (ORCID: https://orcid.org/0000-0002-7802-0875)
- Akshay Jatin Patel (ORCID: https://orcid.org/0000-0001-9170-8618)
- Sophia Tsoka (ORCID: https://orcid.org/0000-0001-8403-1282)
- Eleftherios P. Diamandis (ORCID: https://orcid.org/0000-0002-1589-820X)
- Katie E. Lacy (ORCID: https://orcid.org/0000-0001-9694-9197)
- Katie Stoker (ORCID: https://orcid.org/0009-0002-7889-7164)
- Sean Whittaker (ORCID: https://orcid.org/0000-0003-0972-2600)
- Zena Willsmore (ORCID: https://orcid.org/0000-0001-8750-804X)
- Amanda Fitzpartick
Institutions
- Mount Sinai Hospital (CA)
- St Thomas' Hospital (GB)
- University Health Network (CA)
- King's College London (GB)
- University of Toronto (CA)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Breast Cancer Now (GB)
- Yale University (US)
- London Cancer (GB)
- King's College School (GB)
- St. Thomas Hospital (CA)
- NIHR Birmingham Biomedical Research Centre (GB)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1136/jitc-2025-011682
- Citations
- 4
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 4.18
Funders
- Wellcome Trust
- Cancer Research UK
- Royal Society
- British Skin Foundation
- Guy's and St Thomas' Charity