GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis
This study identifies GSTM1 as a key inhibitor of fibroblast activation and cardiac fibrosis, highlighting its ability to target ferroptosis through redox regulation. AAV-mediated GSTM1 therapy demonstrates significant therapeutic potential for improving outcomes post-MI.
Authors
- Hong Ma (ORCID: https://orcid.org/0000-0003-3419-4627)
- Siyu Zhou (ORCID: https://orcid.org/0000-0002-9876-7925)
- Yimin Shen (ORCID: https://orcid.org/0000-0002-2993-665X)
- Shuo Yu (ORCID: https://orcid.org/0000-0002-7988-0551)
- Kai‐Jie Chen (ORCID: https://orcid.org/0000-0001-7581-6571)
- Yao Xie (ORCID: https://orcid.org/0000-0002-3175-0213)
- Chong Wei Jin (ORCID: https://orcid.org/0000-0003-0896-8596)
- Yue Zhang (ORCID: https://orcid.org/0000-0001-6153-9833)
- Zhihui Huang (ORCID: https://orcid.org/0000-0003-4457-6346)
- Lan Xie (ORCID: https://orcid.org/0000-0001-5831-8730)
- Hui Gong (ORCID: https://orcid.org/0000-0002-6718-9341)
- Xiao-Ce Dai
- Xin-Yi Zhu
- Sheng-an Su
- Mei-Xiang Xiang
Institutions
- Zhejiang University of Science and Technology (CN)
- Fudan University (CN)
- Zhongshan Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University of Technology (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Military Medical Research
- Published
- 2025-05-30
- DOI
- https://doi.org/10.1186/s40779-025-00610-6
- Citations
- 4
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- National Natural Science Foundation of China
- Medical Science and Technology Project of Zhejiang Province
- Natural Science Foundation of Zhejiang Province