HISTOPATHOLOGICAL AND BIOCHEMICAL ANALYSIS OF SELECTED ORGANS OF CATTLE INFECTED WITH BOVINE BABESIOSIS

The current study aims to investigate the effects of babesiosis infection on biochemical parameters, oxidative stress biomarkers, and the histopathological changes on the spleen, kidneys, and liver.The blood of 110 animals were collected.Biochemical screenings for antioxidant and oxidant markers, as well as kidney and liver function testing.Liver, kidney, and spleen samples were examined using histology and immunohistochemistry in this study.The Babesia organism was detected in Giemsa-stained blood smears in 42 cattle.When compared to a healthy control (44 cattle), animals infected with Babesia had significantly higher levels of serum liver and kidney function.Oxidative stress in Babesia-infected animals was an increase and a significant drop in the activity of antioxidants relative to the healthy control.In addition, the current study found that Babesia bovis caused significant degeneration in the spleen, kidney, and liver histopathological structures, along with an increase in collagen fiber deposition, decrease in BCL-2 positive cells and an upregulation of CD3+ cells in the spleen.The findings of this study suggest that Babesiosis can impair antioxidant defenses and increase oxidative markers.Therefore, in addition to Babesicidal drugs, antioxidants can be used as a supportive therapy for a better and faster recovery.