Aqueous leaf extract of Vitex negundo modulates M1-M2 phenotypic switch and functional changes in human macrophages in an in vitro model of hypertension
The results suggest the potential of ALE of V. negundo in exerting immunomodulatory effects in an in vitro model of angiotensin II-mediated hypertension mainly by modulating M1-M2 macrophage switch and limiting inflammation and production of pro-oxidants.
Authors
- Boniface Makori Nyamweya (ORCID: https://orcid.org/0000-0003-4712-9445)
- Rajiva de Silva
- Dilani Rukshala (ORCID: https://orcid.org/0000-0001-6149-9181)
- Narmada Fernando (ORCID: https://orcid.org/0000-0001-5899-9564)
- Sunil Premawansa (ORCID: https://orcid.org/0000-0001-7841-8683)
- Shiroma Handunnetti
Institutions
- Medical Research Institute (LK)
- University of Colombo (LK)
Publication Details
- Journal
- Journal of Ayurveda and Integrative Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jaim.2025.101148
- Citations
- 2
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.61