Withaferin A reduces pulmonary eosinophilia and IL-25 production in a mouse model of allergic airways disease
This study pinpoints a potential mechanism by which WFA modulates allergen-induced airway eosinophilia via the IL-25 signaling pathway. Future studies will investigate the effects of WFA administration on lung eosinophilia and IL-25 signaling in the context of chronic allergen-challenge.
Authors
- Jennifer L. Ingram (ORCID: https://orcid.org/0000-0002-5269-8864)
- V. Mcquade
- Jack T. Womble (ORCID: https://orcid.org/0000-0001-8194-5038)
- Sanat Phatak (ORCID: https://orcid.org/0000-0002-3548-9956)
- Marissa A. Guttenberg (ORCID: https://orcid.org/0000-0003-1737-8002)
- K. Agner
Institutions
- Duke University (US)
- Duke Medical Center (US)
- King Edward Memorial Hospital Research Centre (IN)
Publication Details
- Journal
- Journal of Ayurveda and Integrative Medicine
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1016/j.jaim.2025.101144
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- The Wellcome Trust DBT India Alliance
- National Institutes of Health