Mesocorticolimbic dopaminergic innervation modulates Levodopa-related improvements in gait in older slow walking Adults: A [11C]PE2I PET study
These preliminary findings suggest that the mesocorticolimbic dopaminergic system may be the substrate of a resilience mechanism that can be targeted to manage gait impairments in older adults.
Authors
- Prabesh Kanel (ORCID: https://orcid.org/0000-0003-1418-2960)
- Lana M. Chahine (ORCID: https://orcid.org/0000-0003-2521-7196)
- Miriam van Emde Boas (ORCID: https://orcid.org/0009-0008-3942-3330)
- Stiven Roytman (ORCID: https://orcid.org/0000-0001-8823-3287)
- Giulia Carli (ORCID: https://orcid.org/0000-0001-7216-2031)
- Chatkaew Pongmala (ORCID: https://orcid.org/0000-0002-1738-0105)
- A Luker
- Robert A. Koeppe (ORCID: https://orcid.org/0000-0002-9514-5311)
- Caterina Rosano (ORCID: https://orcid.org/0000-0002-0909-1506)
- Fotini Michalakis (ORCID: https://orcid.org/0009-0006-0836-445X)
- Abigail M Biddix
- Nicolaas Ida Bohnen (ORCID: https://orcid.org/0000-0003-0352-6414)
- N Paalanen
Institutions
- University of Pittsburgh (US)
- University of Michigan (US)
- VA Ann Arbor Healthcare System (US)
- Michigan Medicine (US)
- VA Center for Clinical Management Research (US)
- Parkinson's Foundation (US)
Publication Details
- Journal
- Clinical Parkinsonism & Related Disorders
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.prdoa.2025.100353
- Citations
- 3
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 4.29