Rare metastasis of renal cell carcinoma to the breast: a case report.

Renal cell carcinoma is an aggressive urological malignancy, accounting for 2%-3% of adult cancers and over 90% of renal cancers. While renal cell carcinoma commonly metastasizes to organs such as the lungs, bones, and liver, breast metastasis is rare, comprising only 0.5% to 2% of all breast neoplasms. This case report describes a 54-year-old female with a history of RCC who developed a metastatic lesion in her breast six years after radical nephrectomy. The lesion, initially detected via routine imaging, was confirmed as renal cell carcinoma through histopathology and immunohistochemistry. A wide local excision was performed, avoiding unnecessary axillary surgery. This case highlights the need for meticulous diagnostic evaluation to distinguish between primary breast carcinoma and metastatic disease, particularly in patients with a history of renal cell carcinoma. The rarity of renal cell carcinoma metastasis to the breast calls for further research to guide appropriate management.

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Publication Details

Journal
PubMed
Published
2025-05-01
DOI
https://doi.org/10.1093/omcr/omaf029
Primary Topic
Breast Lesions and Carcinomas
Type
article
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0.00
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article

Rare metastasis of renal cell carcinoma to the breast: a case report.

Lilia Ragad, Rasheed Elayyan, Aman Saswat Sahoo, Bhavya Singh et al.
2 links
PubMed
Breast Lesions and Carcinomas
article

Rare metastasis of renal cell carcinoma to the breast: a case report.

Lilia Ragad, Rasheed Elayyan, Aman Saswat Sahoo, Bhavya Singh, Mahmoud Salman
article en

Abstract

Renal cell carcinoma is an aggressive urological malignancy, accounting for 2%-3% of adult cancers and over 90% of renal cancers. While renal cell carcinoma commonly metastasizes to organs such as the lungs, bones, and liver, breast metastasis is rare, comprising only 0.5% to 2% of all breast neoplasms. This case report describes a 54-year-old female with a history of RCC who developed a metastatic lesion in her breast six years after radical nephrectomy. The lesion, initially detected via routine imaging, was confirmed as renal cell carcinoma through histopathology and immunohistochemistry. A wide local excision was performed, avoiding unnecessary axillary surgery. This case highlights the need for meticulous diagnostic evaluation to distinguish between primary breast carcinoma and metastatic disease, particularly in patients with a history of renal cell carcinoma. The rarity of renal cell carcinoma metastasis to the breast calls for further research to guide appropriate management.

PubMedVol. 2025(5)
University of Lancashire (GB), King's College Hospital (GB)
Openalex Percentile: Top 82%
Breast Lesions and Carcinomas
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