BPIFB1 is a prognostic biomarker and mediated collagen synthesis in idiopathic pulmonary fibrosis

It has been demonstrated that bactericidal/permeability-increasing-fold-containing family B member 1 (BPIFB1) is highly expressed in idiopathic pulmonary fibrosis (IPF) and is linked to a dismal prognosis; nevertheless, its molecular role and connection to lung function in IPF are still unknown. The Gene Expression Omnibus database provided the data. Functional enrichment analyses, Kaplan-Meier, Cox regression, and the Pearson correlation coefficient were applied. Studies and single-cell ribonucleic acid sequencing research verified the impact of BPIFB1 on IPF. BPIFB1 was highly expressed in differentiating ciliated cells and MUC5B + cells, and single-cell sequencing and transcriptome analysis revealed that it was up-regulated in the lungs of IPF; however, blood BPIFB1 expression was similar in the control group and IPF. In addition, we identified 24 genes that interact with BPIFB1 and the top 5 transcription factors that target these genes as reported by the hTFtarget database. Clinical samples show that in the IPF, BPIFB1 is inversely correlated with lung function. According to bioinformatics analysis, elevated levels of BPIFB1 expression might be correlated with lung fibroblast differentiation and collagen synthesis. BPIFB1 may be a useful indicator of the prognosis and severity of the IPF. BPIFB1 may be associated with lung fibroblast differentiation and collagen production.