Repeated plasma p‐tau217 measurements to monitor clinical progression heterogeneity
k-Means found stable, slow, and rapid cognitive decline clusters in amyloid beta-positive (Aβ+) cases. Higher baseline plasma phosphorylated tau-217 (p-tau217) levels predicted faster cognitive decline. Longitudinal increases in plasma p-tau217 were steepest in rapid decliners. Plasma p-tau217 tracks clinical progression heterogeneity in Aβ+ cases. Cognitive stage and amyloid alone may miss severity and risk in early-stage Alzheimer's disease.
Authors
- Lene Pålhaugen
- Ragnhild Eide Skogseth (ORCID: https://orcid.org/0000-0001-6688-9955)
- Argonde C. van Harten (ORCID: https://orcid.org/0000-0002-1477-8724)
- Michael Turton
- Berglind Gísladóttir (ORCID: https://orcid.org/0000-0002-1787-3006)
- Kaj Blennow (ORCID: https://orcid.org/0000-0002-1890-4193)
- Bjørn‐Eivind Kirsebom (ORCID: https://orcid.org/0000-0002-1413-9578)
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Knut Waterloo (ORCID: https://orcid.org/0000-0003-3447-8312)
- Tormod Fladby (ORCID: https://orcid.org/0000-0002-9984-9797)
- Geir Bråthen (ORCID: https://orcid.org/0000-0003-3224-7983)
- Jonas Alexander Jarholm
- Arvid Rongve (ORCID: https://orcid.org/0000-0002-0476-4134)
- Sinthujah Vigneswaran
- Per Selnes
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
- Peter Harrison
- Betty Tjims
Institutions
- University of Science and Technology of China (CN)
- University Hospital of North Norway (NO)
- University of Oslo (NO)
- Norwegian University of Science and Technology (NO)
- Akershus University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Privatsykehuset Haugesund (NO)
- Sorbonne Université (FR)
- St Olav's University Hospital (NO)
- Amsterdam Neuroscience (NL)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- Haraldsplass Diakonale Sykehus (NO)
- National Hospital for Neurology and Neurosurgery (GB)
- Amsterdam University Medical Centers (NL)
- Institut du Cerveau (FR)
- University of Bergen (NO)
- University College London (GB)
- UiT The Arctic University of Norway (NO)
- Vrije Universiteit Amsterdam (NL)
- University of Gothenburg (SE)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Publication Details
- Journal
- Alzheimer s & Dementia
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1002/alz.70319
- Citations
- 9
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 13.24
Funders
- Alzheimer's Association
- Familjen Erling-Perssons Stiftelse
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- European Partnership on Metrology
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- Norges Forskningsråd
- UK Dementia Research Institute
- Fondation pour la Recherche sur Alzheimer
- HORIZON EUROPE Framework Programme