Clozapine as a Long-Term Therapeutic Choice: Longitudinal Analysis of Schizophrenia Symptoms in a Naturalistic Setting
In this naturalistic study, clozapine was associated with substantial symptom improvement, particularly within the first year. A subset of patients demonstrated delayed but clinically meaningful response, supporting the continued use of clozapine beyond 12 months. These findings underscore the value of sustained treatment in TRS.
Authors
- Gayane Yenokyan (ORCID: https://orcid.org/0000-0003-1482-5612)
- Laura Scott (ORCID: https://orcid.org/0000-0002-5587-5643)
- Arlene Cuerdo
- Zheng Fu (ORCID: https://orcid.org/0000-0003-2618-2853)
- Frederick C. Nucifora
- Krista K. Baker
- Ligang Zhong (ORCID: https://orcid.org/0000-0003-3600-2457)
- Max Harper
- Leslie G. Nucifora (ORCID: https://orcid.org/0000-0002-9678-3526)
- Allison Brandt
- Rachel Scheinberg
- Russell L. Margolis (ORCID: https://orcid.org/0000-0003-3024-8595)
- Chloe Bethany
Institutions
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Johns Hopkins Bayview Medical Center (US)
- Behavioral Pharma (United States) (US)
- Banner - University Medical Center Tucson (US)
- South University (US)
Publication Details
- Journal
- Schizophrenia Bulletin Open
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1093/schizbullopen/sgaf009
- Primary Topic
- Schizophrenia research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Johns Hopkins University