<i>APOE</i> ε4‐independent pathways predominate in the association between retinal nerve fiber layer thinning and 12‐year incident dementia
The association between <i>APOE</i> ε4 carriers and thinner RNFL was solidified by the J-T test and multiple linear regression, indicating genetic influence on retinal structure.After inverse probability weighting adjustment, each 5-µm reduction in baseline RNFL thickness increased dementia risk by 15%, highlighting its long-term predictive value.Only 7.6% of the effect of RNFL thickness on dementia risk was attributable to <i>APOE</i> status, underscoring the value of RNFL as a standalone, non-invasive biomarker in the assessment of long-term dementia risk.
Authors
- Qianhua Zhao (ORCID: https://orcid.org/0000-0001-5655-158X)
- Han Cen (ORCID: https://orcid.org/0000-0002-9251-2331)
- Xiaoxi Ma (ORCID: https://orcid.org/0000-0001-7403-3700)
- Ding Ding (ORCID: https://orcid.org/0000-0002-3260-7515)
- Jie Wang (ORCID: https://orcid.org/0009-0005-4386-7338)
- Yuzhuo Wang
- Jie Wu (ORCID: https://orcid.org/0000-0003-4028-6173)
- Yiqin Xiao
Institutions
- Shanghai University of Finance and Economics (CN)
- Fudan University (CN)
- Huashan Hospital (CN)
Publication Details
- Journal
- Alzheimer s & Dementia Translational Research & Clinical Interventions
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/trc2.70104
- Primary Topic
- Retinal Imaging and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China