Small extracellular vesicles from human umbilical cord mesenchymal stem cells delivering miR-202-5p alleviate renal ischemia-reperfusion injury by targeting the GOLIM4/PI3K/AKT axis
This study is the first to demonstrate the role of HucMSC-sEVs in attenuating renal IRI both <i>in vitro</i> and <i>in vivo</i> through the modulation of the GOLIM4/PI3K/AKT pathway via miR-202-5p. These findings identify a novel molecular target for the treatment of AKI via HucMSC-sEVs and provide a strong theoretical basis for their potential clinical application.
Authors
- Yongpeng Xie (ORCID: https://orcid.org/0000-0001-5787-5463)
- Zhenwei Feng
- Xin Gou (ORCID: https://orcid.org/0000-0003-3062-209X)
- Xiang Peng
- Zongjie Wei
- Haitao Yu (ORCID: https://orcid.org/0000-0002-9745-8418)
- Weiyang He (ORCID: https://orcid.org/0000-0003-4861-7555)
- Wei Shi (ORCID: https://orcid.org/0009-0008-8078-3872)
Institutions
- University of California, Los Angeles (US)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Children's Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1586174
- Citations
- 3
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Chongqing Science and Technology Foundation