Integrated UPLC–MS/MS and UPLC–Q–TOF–MS/MS analysis to reveal pharmacokinetics, tissue distribution, metabolism, and excretion of sipeimine in rats
The pharmacokinetics, tissue distribution, metabolism, and excretion of sipeimine were comprehensively characterized and elucidated. These results are expected to prove useful for the interpretation of the pharmacokinetic and pharmacodynamic characteristics of sipeimine and the traditional Chinese medicines containing sipeimine.
Authors
- Dongdong He (ORCID: https://orcid.org/0000-0002-5786-581X)
- Juanjuan Wan
- D D Li
- Hui Zong (ORCID: https://orcid.org/0000-0002-4263-9633)
- Liping Wang (ORCID: https://orcid.org/0000-0002-9282-2751)
- Meiling Zhang (ORCID: https://orcid.org/0000-0002-8882-2564)
- Chongyang Wang (ORCID: https://orcid.org/0000-0001-8943-7214)
- Hui Tang (ORCID: https://orcid.org/0000-0002-7274-1487)
- Li‐Ting Liu (ORCID: https://orcid.org/0000-0002-7641-4774)
- Jun Ran
- Guodong Wang (ORCID: https://orcid.org/0000-0001-5191-7327)
Institutions
- Shihezi University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fphar.2025.1595731
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shihezi University
- Xinjiang Production and Construction Corps