Distribution characteristics and prognostic value of TIM-1 in patients with lung adenocarcinoma
Our findings confirm the immunosuppressive role of TIM-1+B cells in LUAD and suggest that TIM-1+B cells exert immune suppression by inhibiting TLS maturation and CD8+ T cell density. These findings highlight TIM-1+ B cells as a potential therapeutic target.
Authors
- Xiaoyan Yin (ORCID: https://orcid.org/0000-0002-2141-3934)
- Wenhua Yun
- Jun Wen (ORCID: https://orcid.org/0000-0003-2929-1270)
- Wenxing Cui
- Yu Chen (ORCID: https://orcid.org/0000-0001-6126-0082)
- Minghao Yu
- Xiangjiao Meng
Institutions
- Shandong Tumor Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1602868
- Primary Topic
- Galectins and Cancer Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province