Ethanol‐induced Nrf2 suppression in the lung is mediated by <scp>AP</scp>‐1‐driven expression of mi<scp>R</scp>‐144
Ethanol induces miR-144 expression in the lung, mediated by AP-1 activation. These steps can be implicated in the ethanol-mediated inhibition of Nrf2 and the downstream suppression of Nrf2-dependent antioxidant and immune defenses. These results suggest that miR-144 could be a novel therapeutic target to mitigate susceptibility to acute inflammatory lung diseases in individuals with AUD.
Authors
- Hui Tao (ORCID: https://orcid.org/0000-0002-6493-2101)
- Viranuj Sueblinvong (ORCID: https://orcid.org/0000-0002-4770-5900)
- David M. Guidot (ORCID: https://orcid.org/0000-0002-9752-5334)
- Xian Fan (ORCID: https://orcid.org/0000-0002-7693-1907)
- J. Guo (ORCID: https://orcid.org/0009-0000-1762-5865)
Institutions
- Emory University (US)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2025-05-29
- DOI
- https://doi.org/10.1111/acer.70088
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- National Institute on Alcohol Abuse and Alcoholism