Determination of nine prostaglandins in the arachidonic acid metabolic pathway with UHPLC-QQQ-MS/MS and application to in vitro and in vivo inflammation models
The method established in this study for determining nine prostaglandins in the AA metabolic pathway with UHPLC-QQQ-MS/MS embodied the advantages of requiring a low amount of sample, a simple pretreatment process, and the rapid and efficient simultaneous quantification of multiple inflammatory factors. It provided a novel assay method for the pharmacological study of the AA metabolic pathway.
Authors
- M.Z. Wang
- Xiaotong Wang (ORCID: https://orcid.org/0000-0002-5329-2663)
- Xinxin Wang (ORCID: https://orcid.org/0000-0002-0286-3681)
- Fan He (ORCID: https://orcid.org/0000-0002-1509-5845)
- Ziqi Yang (ORCID: https://orcid.org/0009-0009-4995-7085)
- Yu‐Feng Huang (ORCID: https://orcid.org/0000-0002-7165-5931)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fphar.2025.1595059
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China