Transcriptional profiling reveals H.pylori-associated genes induced inflammatory cell infiltration and chemoresistance in gastric cancer
The HPI, reflecting newly identified and complementary biomarkers, correlated with the TME and could accurately project chemoresistance and an altered immune cell distribution in GC patients, thus providing clinical guidance on therapeutic interventions.
Authors
- Zhengxin Wu (ORCID: https://orcid.org/0000-0001-5610-8086)
- Huiqin Zhuo (ORCID: https://orcid.org/0000-0001-8322-4197)
- Jinshui Tan
- Zhiruo Liu (ORCID: https://orcid.org/0000-0003-3696-5560)
- Xuehui Hong (ORCID: https://orcid.org/0000-0002-8853-7384)
- Yubo Xiong
- Wei Wang (ORCID: https://orcid.org/0000-0001-7358-6557)
- Guangchao Pan
- Huiwen Zhou (ORCID: https://orcid.org/0000-0003-4793-5068)
- Jingsong Ma
- Yuankun Liu (ORCID: https://orcid.org/0009-0009-3600-1586)
- Jiabao Zhao (ORCID: https://orcid.org/0000-0002-0691-5741)
- Wenjuan Qin (ORCID: https://orcid.org/0009-0004-6782-2321)
- Haijie Lu
Institutions
- Zhejiang Chinese Medical University (CN)
- Xiamen University (CN)
- Zhongshan Hospital of Xiamen University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-05-30
- DOI
- https://doi.org/10.3389/fimmu.2025.1592558
- Citations
- 1
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Natural Science Foundation of China