Open‐Label Randomized Controlled Trial and Feasibility Study of an Oral Probiotic Intervention to Reduce Group B <i>Streptococcus</i> Colonization in Pregnant People by the Time of Birth
The feasibility of a larger RCT was demonstrated. Challenges identified included intrapartum GBS collection and laboratory processing during the COVID-19 pandemic. The study was not powered to detect a significant difference in intrapartum GBS colonization, although a larger decrease in GBS colonization was noted among probiotic-using participants. Florajen Digestion may show efficacy in a RCT with a longer intervention period. It is possible that the probiotic intervention duration was too brief to show a reduction in gastrointestinal pregnancy symptoms.
Authors
- Robyn Lawton
- Lisa Hanson (ORCID: https://orcid.org/0000-0002-5383-4725)
- Adele R. Shields (ORCID: https://orcid.org/0000-0003-1298-4150)
- Katrina Nardini (ORCID: https://orcid.org/0000-0002-5752-0563)
- Maharaj Singh (ORCID: https://orcid.org/0000-0001-7736-1291)
- Noelle Borders
- Emily Malloy (ORCID: https://orcid.org/0000-0002-1608-1197)
- V. Trujillo (ORCID: https://orcid.org/0009-0004-6093-5905)
Institutions
- Marquette University (US)
- University of New Mexico (US)
- Medica (United States) (US)
- Aurora Sinai Medical Center (US)
- Aurora University (US)
Publication Details
- Journal
- Journal of Midwifery & Women s Health
- Published
- 2025-05-01
- DOI
- https://doi.org/10.1111/jmwh.13765
- Citations
- 1
- Primary Topic
- Neonatal and Maternal Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.88
Funders
- Marquette University