To Investigate the Therapeutic Effect and Mechanism of "Ginger-Mume" Based on Bibliometrics and Network Pharmacology

In this study, bibliometrics and network pharmacology were used to explore the effect and mechanism of Ginger and Fructus Mume in the field of disease treatment. The research method is to construct a global distribution network of literatures related to "Ginger-Mume" by bibliometrix using the R package; the chemical composition and targets of "Ginger-Mume" are searched using TCMSP, BATMAN-TCM, Swiss, SEA, UniProt and other databases, and the disease targets are searched using the CTD database, followed by GO analysis and KEGG pathway enrichment analysis using the DAVID database. The results showed that a total of 34 eligible compounds, 525 targets, and 29 diseases were screened. GO analysis showed that biological function was extremely closely related to mitochondria. The most relevant pathway in KEGG analysis was the chemical carcinogenic risk factor-reactive oxygen species pathway. The results showed that "Ginger-Mume" through multi-component, multi-target, multi-way treatment of a variety of diseases, especially diabetes, cancer, genitourinary system, digestive system, cardiovascular system and other diseases have a significant effect, pointing out the direction for future drug research.